Patient Information Leaflet
Print this leaflet and bring it to your next appointment.
LevWise — Patient Information Leaflet
levwise.org
What is this leaflet?
This leaflet is designed to help you have an informed conversation with your neurologist or GP about levetiracetam (Keppra). It summarises the key evidence and provides questions you may wish to ask. It is not medical advice — always discuss treatment decisions with your doctor.
6 Questions to Ask Your Neurologist
What type of epilepsy do I have — focal, generalised, or unknown? Does this affect which drug is best for me?
Is levetiracetam the most effective first-line option for my specific epilepsy type, given the SANAD II trial results?
What are the neuropsychiatric risks of levetiracetam, and how will we monitor for them?
Do I have any risk factors (psychiatric history, high dose, age) that make neuropsychiatric side effects more likely?
If this drug does not control my seizures, how will we determine whether my epilepsy is truly drug-resistant or whether a different drug choice might work?
Are there alternative antiepileptic drugs that might be better suited to my situation?
Warning Signs to Watch For
Increased irritability or aggression
10–20% of patients. Report to your doctor if it affects relationships or daily life.
Low mood or depression
13% of patients. Seek help promptly — do not wait for the next scheduled appointment.
Thoughts of self-harm or suicide
Seek emergency help immediately. All antiepileptic drugs carry a class warning for suicidality.
Rash with fever or swollen glands
May indicate DRESS — a rare but serious reaction. Stop the drug and seek emergency care.
Memory or concentration problems
Cognitive effects are reported. Discuss with your doctor if affecting work or daily activities.
Behavioural changes in children
Parents should monitor closely. Aggression, emotional lability, and regression have been reported.
What the Evidence Shows
Important Disclaimer
This leaflet is for informational and educational purposes only. It does not constitute medical advice and should not be used to make treatment decisions without consulting a qualified healthcare professional. Never stop or change your medication without medical supervision — sudden changes to antiepileptic drugs can cause serious harm.
LevWise — Evidence-Based Information on Levetiracetam | levwise.org